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Associations of ambient manganese exposure with brain gray matter thickness and white matter hyperintensities

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2023-12-05 15:11
조회수
94
Issue Date
2023-08
Type
Article

Authors: Shinyoung Woo ; Young Noh ; Sang-Baek Koh ; Seung-Koo Lee ; Jung Il Lee ; Ho Hyun Kim ; Sun- Young Kim ; Jaelim Cho ; Changsoo Kim

Citation: HYPERTENSION RESEARCH, Vol.46(8) : 1870-1879, 2023-08

Journal Title: HYPERTENSION RESEARCH

ISSN: 0916-9636

Issue Date: 2023-08

MeSH: Adult ; Brain / diagnostic imaging ; Cerebrovascular Disorders* ; Dementia* / chemically induced ; Female ; Gray Matter / diagnostic imaging ; Gray Matter / pathology ; Humans ; Magnetic Resonance Imaging / methods ; Male ; Manganese / adverse effects ; White Matter* / diagnostic imaging

Keywords: Brain MRI marker ; Manganese exposure ; White matter hyperintensity

Abstract: Manganese (Mn) exposure is associated with increased risks of dementia and cerebrovascular disease. However, evidence regarding the impact of ambient Mn exposure on brain imaging markers is scarce. We aimed to investigate the association between ambient Mn exposure and brain imaging markers representing neurodegeneration and cerebrovascular lesions. We recruited a total of 936 adults (442 men and 494 women) without dementia, movement disorders, or stroke from the Republic of Korea. Ambient Mn concentrations were predicted at each participant's residential address using spatial modeling. Neurodegeneration-related brain imaging markers, such as the regional cortical thickness, were estimated using 3 T brain magnetic resonance images. White matter hyperintensity volume (an indicator of cerebrovascular lesions) was also obtained from a certain number of participants (n = 397). Linear regression analyses were conducted after adjusting for potential confounders. A log-transformed ambient Mn concentration was associated with thinner parietal (β = -0.02 mm; 95% confidence interval [CI], -0.05 to -0.01) and occipital cortices (β = -0.03 mm; 95% CI, -0.04 to -0.01) after correcting for multiple comparisons. These associations remained statistically significant in men. An increase in the ambient Mn concentration was also associated with a greater volume of deep white matter hyperintensity in men (β = 772.4 mm3, 95% CI: 36.9 to 1508.0). None of the associations were significant in women. Our findings suggest that ambient Mn exposure may induce cortical atrophy in the general adult population.

Full Text: https://www.nature.com/articles/s41440-023-01291-1

DOI: 10.1038/s41440-023-01291-1

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

Yonsei Authors: Kim, Chang Soo(김창수) https://orcid.org/0000-0002-5940-5649
Lee, Seung Koo(이승구) https://orcid.org/0000-0001-5646-4072
Cho, Jae Lim(조재림)

URI: https://ir.ymlib.yonsei.ac.kr/handle/22282913/196238

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